CAS 39968-33-7
HOAt
1-Hydroxy-7-azabenzotriazole · C₅H₄N₄O · MW 136.11
Purity
≥ 98% (HPLC)
Grade
Peptide Grade
Availability
In Stock
Overview
HOAt (1-Hydroxy-7-azabenzotriazole, CAS 39968-33-7) is a peptide coupling additive for SPPS and solution-phase synthesis. Forms reactive OAtester intermediates for efficient amide bond formation. Purity ≥ 98% (HPLC), peptide synthesis grade. Compatible with HATU, PyAOP, DIC, and EDC coupling systems.
Supply & Packaging
Packaging
5 g, 25 g, 100 g, 500 g; custom sizes on request
Storage
2–8 °C, sealed, protected from light and moisture. Shelf life: 24 months.
Solubility
Soluble in DMF, DMSO, and NMP
Payment
T/T, L/C at sight
Sample
Available on request
Applications
Racemization-Sensitive Coupling
Coupling steps requiring stereochemical integrity in chiral-sensitive peptide sequences.
Fragment Condensation
Convergent peptide synthesis involving protected segment coupling.
Sterically Hindered Substrates
Aib, α-methylated residues, N-methylated amino acids, and other difficult coupling partners.
Peptide API Process
Research and production workflows in peptide and peptidomimetic synthesis.
Standards
FAQ
HOAt forms reactive OAt ester intermediates with better racemization suppression in difficult couplings. Practical selection depends on substrate and process objectives.
HATU, PyAOP, DIC, and EDC coupling systems.
2–8 °C, sealed, protected from light and moisture. Shelf life: 24 months.
5 g, 25 g, 100 g, and500 g. Custom sizes on request.